Arnold Schwarzenegger portrays Dr. Alex Hesse, a scientist who becomes pregnant as part of a research experiment.
Danny DeVito plays Dr. Larry Arbogast, a colleague and friend of Dr. Hesse involved in the unconventional pregnancy experiment.
Emma Thompson takes on the role of Dr. Diana Reddin, a fellow scientist and collaborator in the pregnancy project.
Frank Langella portrays Noah Banes, a senior figure in the pharmaceutical company funding the pregnancy research.
Pamela Reed plays Angela, a supporting character involved in the events surrounding Dr. Hesse's pregnancy experiment.
Aida Turturro portrays Louise, another character involved in the research project and the events that unfold.
James Eckhouse plays Ned Sneller, a role connected to the scientific and medical world depicted in the movie.
Megan Cavanagh takes on the role of Willow, a character tied to the narrative of Dr. Hesse's journey through pregnancy.
Welker White portrays Jenny, a character involved in the unfolding events surrounding the male pregnancy experiment.
Kathleen Chalfant appears as the Casitas Madres Receptionist, a minor but noteworthy role within the story.
Merle Kennedy plays Samantha, a character who contributes to the various aspects of the movie's plot.
Judy Collins portrays Naomi, a character who plays a part in the events surrounding the male pregnancy experiment.
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