Osmosis Jones Cast
The cast of Osmosis Jones.
Chris Rock
as Osmosis Jones (voice)

Chris Rock lends his voice to the character of Osmosis Jones.

Laurence Fishburne
as Thrax (voice)

Laurence Fishburne voices the character of Thrax.

David Hyde Pierce
as Drix (voice)

David Hyde Pierce voices the character of Drix.

Brandy Norwood
as Leah (voice)

Brandy Norwood lends her voice to the character of Leah.

Bill Murray
as Frank Detorre

Bill Murray portrays the character of Frank Detorre.

Molly Shannon
as Mrs. Boyd

Molly Shannon portrays the character of Mrs. Boyd.

William Shatner
as Mayor Phlegmming (voice)

William Shatner lends his voice to the character of Mayor Phlegmming.

Ron Howard
as Tom Colonic (voice)

Ron Howard provides the voice for the character of Tom Colonic.

Sherry Lynn
as (voice)
Mickie McGowan
as Additional Character Voice (voice)
Chris Elliott
as Bob
Elena Franklin
as Shane Detorre
Kid Rock
as Kidney Rock
Uncle Kracker
as Kidney Rock (voice)
Carlos Alazraqui
as Additional Character Voices (voice)
Rodger Bumpass
as Additional Character Voice (voice)
Richard Steven Horvitz
as Additional Character Voice (voice)
Danny Mann
as Additional Character Voice (voice)
Mickie McGowan
as Additional Character Voices (voice)
Jonathan Adams
as Additional Character Voice
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