Osmosis Jones Cast
The cast of Osmosis Jones including popularity data. Data for April 22, 2025.
Chris Rock
as Osmosis Jones (voice)

Chris Rock lends his voice to the character of Osmosis Jones.

#6
Most popular actor on Osmosis Jones
2,934 Wikipedia views yesterday
Laurence Fishburne
as Thrax (voice)

Laurence Fishburne voices the character of Thrax.

#3
Most popular actor on Osmosis Jones
5,928 Wikipedia views yesterday
David Hyde Pierce
as Drix (voice)

David Hyde Pierce voices the character of Drix.

#2
Most popular actor on Osmosis Jones
7,247 Wikipedia views yesterday
Brandy Norwood
as Leah (voice)

Brandy Norwood lends her voice to the character of Leah.

#9
Most popular actor on Osmosis Jones
2,139 Wikipedia views yesterday
Bill Murray
as Frank Detorre

Bill Murray portrays the character of Frank Detorre.

#5
Most popular actor on Osmosis Jones
4,759 Wikipedia views yesterday
Molly Shannon
as Mrs. Boyd

Molly Shannon portrays the character of Mrs. Boyd.

#7
Most popular actor on Osmosis Jones
2,925 Wikipedia views yesterday
William Shatner
as Mayor Phlegmming (voice)

William Shatner lends his voice to the character of Mayor Phlegmming.

#4
Most popular actor on Osmosis Jones
5,423 Wikipedia views yesterday
Ron Howard
as Tom Colonic (voice)

Ron Howard provides the voice for the character of Tom Colonic.

#1
Most popular actor on Osmosis Jones
7,887 Wikipedia views yesterday
Sherry Lynn
as (voice)
Mickie McGowan
as Additional Character Voice (voice)
Chris Elliott
as Bob
#10
Most popular actor on Osmosis Jones
1,576 Wikipedia views yesterday
Elena Franklin
as Shane Detorre
Kid Rock
as Kidney Rock
#8
Most popular actor on Osmosis Jones
2,757 Wikipedia views yesterday
Uncle Kracker
as Kidney Rock (voice)
#13
Most popular actor on Osmosis Jones
531 Wikipedia views yesterday
Carlos Alazraqui
as Additional Character Voices (voice)
#11
Most popular actor on Osmosis Jones
713 Wikipedia views yesterday
Rodger Bumpass
as Additional Character Voice (voice)
#14
Most popular actor on Osmosis Jones
492 Wikipedia views yesterday
Richard Steven Horvitz
as Additional Character Voice (voice)
#12
Most popular actor on Osmosis Jones
634 Wikipedia views yesterday
Danny Mann
as Additional Character Voice (voice)
Mickie McGowan
as Additional Character Voices (voice)
Jonathan Adams
as Additional Character Voice
For the best insights and data about Osmosis Jones, visit our main Osmosis Jones page.