Osmosis Jones Cast
The cast of Osmosis Jones including popularity data. Data for May 12, 2025.
Chris Rock
as Osmosis Jones (voice)

Chris Rock lends his voice to the character of Osmosis Jones.

#6
Most popular actor on Osmosis Jones
2,815 Wikipedia views yesterday
Laurence Fishburne
as Thrax (voice)

Laurence Fishburne voices the character of Thrax.

#3
Most popular actor on Osmosis Jones
4,908 Wikipedia views yesterday
David Hyde Pierce
as Drix (voice)

David Hyde Pierce voices the character of Drix.

#10
Most popular actor on Osmosis Jones
2,209 Wikipedia views yesterday
Brandy Norwood
as Leah (voice)

Brandy Norwood lends her voice to the character of Leah.

#9
Most popular actor on Osmosis Jones
2,343 Wikipedia views yesterday
Bill Murray
as Frank Detorre

Bill Murray portrays the character of Frank Detorre.

#4
Most popular actor on Osmosis Jones
4,449 Wikipedia views yesterday
Molly Shannon
as Mrs. Boyd

Molly Shannon portrays the character of Mrs. Boyd.

#8
Most popular actor on Osmosis Jones
2,354 Wikipedia views yesterday
William Shatner
as Mayor Phlegmming (voice)

William Shatner lends his voice to the character of Mayor Phlegmming.

#1
Most popular actor on Osmosis Jones
11,826 Wikipedia views yesterday
Ron Howard
as Tom Colonic (voice)

Ron Howard provides the voice for the character of Tom Colonic.

#2
Most popular actor on Osmosis Jones
6,217 Wikipedia views yesterday
Sherry Lynn
as (voice)
Mickie McGowan
as Additional Character Voice (voice)
Chris Elliott
as Bob
#7
Most popular actor on Osmosis Jones
2,410 Wikipedia views yesterday
Elena Franklin
as Shane Detorre
Kid Rock
as Kidney Rock
#5
Most popular actor on Osmosis Jones
3,344 Wikipedia views yesterday
Uncle Kracker
as Kidney Rock (voice)
#11
Most popular actor on Osmosis Jones
675 Wikipedia views yesterday
Carlos Alazraqui
as Additional Character Voices (voice)
#13
Most popular actor on Osmosis Jones
623 Wikipedia views yesterday
Rodger Bumpass
as Additional Character Voice (voice)
#14
Most popular actor on Osmosis Jones
459 Wikipedia views yesterday
Richard Steven Horvitz
as Additional Character Voice (voice)
#12
Most popular actor on Osmosis Jones
636 Wikipedia views yesterday
Danny Mann
as Additional Character Voice (voice)
Mickie McGowan
as Additional Character Voices (voice)
Jonathan Adams
as Additional Character Voice
For the best insights and data about Osmosis Jones, visit our main Osmosis Jones page.