Sylvester Stallone plays Raymond 'Ray' Tango, a suave and by-the-book police officer who is framed for a crime he didn't commit.
Kurt Russell portrays Gabriel 'Gabe' Cash, a wisecracking and rule-breaking cop who teams up with Tango to take down the criminals responsible for their predicament.
Teri Hatcher appears as Katherine 'Kiki' Tango, the younger sister of Ray Tango who helps her brother and Cash in their mission to clear their names.
Jack Palance plays Yves Perret, the main villain orchestrating the elaborate scheme to frame Tango and Cash and take control of the criminal underworld.
Brion James portrays Requin, one of Perret's henchmen who serves as a formidable antagonist for Tango and Cash throughout the film.
James Hong appears as Quan, a resourceful and skilled ally who aids Tango and Cash in their mission to uncover the truth behind their setup.
Marc Alaimo plays Lopez, a corrupt police officer working for Perret and serving as an obstacle for Tango and Cash in their pursuit of justice.
Philip Tan portrays the Chinese Gunman, a deadly hitman hired by Perret to eliminate Tango and Cash as they get closer to exposing the truth.
Michael J. Pollard appears as Owen, a quirky inventor who provides Tango and Cash with gadgets and tools to aid them in their mission.
Robert Z'Dar plays the character Face, one of Perret's intimidating henchmen who poses a physical threat to Tango and Cash throughout the film.
Lewis Arquette portrays Wyler, a quirky and eccentric individual who assists Tango and Cash in their investigation with his unique skills and knowledge.
Edward Bunker plays Capt. Holmes, a tough and no-nonsense police captain overseeing Tango and Cash's case and providing them with crucial support.
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