The Big Sick

Kumail Nanjiani plays the role of Kumail Nanjiani, the protagonist of the film. He is a stand-up comedian and actor.

Zoe Kazan portrays the character of Emily Gardner, the love interest of Kumail. She is an American actress and screenwriter.

Holly Hunter plays the role of Beth Gardner, Emily's mother. She is an acclaimed American actress.

Ray Romano portrays the character of Terry Gardner, Emily's father. He is an American comedian and actor.

Anupam Kher plays the role of Azmat Nanjiani, Kumail's father. He is an Indian actor and former chairman of the Film and Television Institute of India.

Zenobia Shroff portrays the character of Sharmeen Nanjiani, Kumail's mother. She is an Indian-American actress.

Adeel Akhtar plays the role of Naveed Nanjiani, Kumail's brother. He is a British actor.

Bo Burnham portrays the character of CJ, Kumail's fellow stand-up comedian. He is an American comedian, musician, actor, and filmmaker.