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I Know This Much Is True
Cast
78 cast members · 24 with popularity data
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Sorted by Buzz Score · April 20, 2026
1
Tatanka Means
Nabby Drinkwater
· 2 eps
4.4
#764 overall
2
Mark Ruffalo
Dominick Birdsey / Thomas Birdsey
· 6 eps
4.4
#794 overall
3
Juliette Lewis
Nedra Frank
· 2 eps
3.2
#1,340 overall
4
Imogen Poots
Joy Hanks
· 3 eps
2.3
#2,063 overall
5
Rosie O'Donnell
Lisa Sheffer
· 6 eps
2.2
#2,228 overall
6
Kathryn Hahn
Dessa Constantine
· 6 eps
1.9
#2,554 overall
7
Bruce Greenwood
Dr. Hume
· 2 eps
1.7
#2,991 overall
8
Melissa Leo
Concettina Ipolita Tempesta 'Ma' Birdsey
· 6 eps
1.1
#4,303 overall
9
Archie Panjabi
Dr. Patel
· 6 eps
1.0
#4,622 overall
10
Laura Silverman
Kristin
· 1 eps
0.8
#6,017 overall
11
Aisling Franciosi
Young Dessa Constantine
· 2 eps
0.7
#6,189 overall
12
Harris Yulin
Father Lavie
· 1 eps
0.6
#7,479 overall
13
Guillermo Díaz
Sergeant Mercado
· 1 eps
0.5
#8,053 overall
14
Felix Solis
Nurse
· 1 eps
0.4
#9,645 overall
15
Brian Goodman
Al
· 1 eps
0.3
#10,091 overall
16
Rob Huebel
Leo
· 6 eps
0.3
#11,493 overall
17
Michael Greyeyes
Ralph Drinkwater
· 6 eps
0.2
#12,107 overall
18
Joe Grifasi
Steve Falice
· 1 eps
0.1
#17,150 overall
19
Philip Ettinger
Early Adulthood Dominick Birdsey / Thomas Birdsey
· 2 eps
0.1
#17,246 overall
20
Marylouise Burke
Librarian
· 1 eps
0.1
#17,771 overall
21
Gina Costigan
Mrs. O'Meara
· 1 eps
0.0
#25,405 overall
22
Laura Esterman
Ruth Hood
· 3 eps
0.0
#25,364 overall
23
Michael Genet
Thomas' Surgeon
· 1 eps
0.0
#26,271 overall
24
Marcello Fonte
Domenico Onofrio Tempesta
· 2 eps
0.0
#27,741 overall
25
John Procaccino
Ray Birdsey
· 6 eps
—
26
Gabe Fazio
Shawn Tudesco / Dominick and Thomas Acting Double
· 6 eps
—
27
Sue Jean Kim
Dr. Yup
· 1 eps
—
28
Michael Simon Hall
Stuart Feinstein
· 1 eps
—
29
Steven Cox
Boyfriend of Dr. Hume's Daughter
· 1 eps
—
30
MorningStar Angeline
Nabby Drinkwater's Wife
· 1 eps
—
31
Al Linea
Abruzzi
· 1 eps
—
32
Richard Fitch
Mill Foreman
· 1 eps
—
33
Amy Lynn Stewart
Merciful Mother
· 1 eps
—
34
Tim Ruddy
Robocop
· 1 eps
—
35
Sandra Berrios
Social Worker at Hatch
· 1 eps
—
36
Christine Parks
Humanities Department Chair
· 1 eps
—
37
Morgan Sullivan
Office Buddy
· 1 eps
—
38
Jake Robards
Landlubbers (voice)
· 1 eps
—
39
María Gonzalez
Ma's Oncology Nurse
· 1 eps
—
40
A.C. Peterson
Gene Diogenes
· 1 eps
—
41
Christopher J. Hanke
Thad
· 1 eps
—
42
James Quattrochi
Bus Driver
· 1 eps
—
43
Rachel B. Joyce
Jeanette
· 1 eps
—
44
Paul Coleman
Support Group Counselor
· 1 eps
—
45
Brandon J. Dirden
Kyle's Dad
· 1 eps
—
46
Katt Masterson
Doreen
· 1 eps
—
47
Jason Furlani
Larry Penn
· 1 eps
—
48
Annie Fitzgerald
Miss Hanker
· 2 eps
—
49
Kate Grimes
English Professor
· 1 eps
—
50
Joseph Ragno
Henrey Rood
· 1 eps
—
51
Acahkos Johnson
Penny Ann Drinkwater
· 2 eps
—
52
Jaiden Klein
Marie Sexton
· 2 eps
—
53
Charlie Reina
Channy
· 2 eps
—
54
Violet Adams
Bunny Borsa
· 2 eps
—
55
Oliver Patnode
Otero
· 2 eps
—
56
Chelsea Sheets
Brunette
· 1 eps
—
57
Matt Helm
Young Leo
· 2 eps
—
58
Derek Goh
17-19 Year Old Dominick & Thomas Acting Double
· 2 eps
—
59
Raymond Neil Hernandez
Omar
· 1 eps
—
60
Simone Coppo
Vincenzo Tempesta
· 1 eps
—
61
Sean Cullen
Dr. Yates
· 1 eps
—
62
Federico Dordei
Nunzio Tucci
· 1 eps
—
63
Agatha Nowicki
Angie Constantine
· 2 eps
—
64
Rocco Masihi
Young Thomas Birdsey
· 4 eps
—
65
Irene Muscara
Prosperina Tucci
· 2 eps
—
66
Adrienne R. Williams
Mrs. Birdsall
· 2 eps
—
67
Shannon Plumb
Charlotte
· 1 eps
—
68
Donnie Masihi
Young Dominick Birdsey
· 4 eps
—
69
Zaria Degenhardt
11 Year Old Concettina
· 1 eps
—
70
Mark A. Gamma
Mourner Mark
· 1 eps
—
71
Wayne J. Miller
Mourner Wayne
· 1 eps
—
72
Thomas Gionet-Lavigne
Ray's Orderly
· 1 eps
—
73
Alexander Hacker
Templeton
· 1 eps
—
74
Robert Mladinich
Paddy Wagon Officer
· 1 eps
—
75
Destry Allyn Spielberg
Dr. Hume's Daughter
· 1 eps
—
76
Roberta Riganò
Ignazia Tempesta
· 1 eps
—
77
Tim Ruddy
Robocop
· 1 eps
—
78
Ethan Crystal
Thin Sailor
· 1 eps
—
I Know This Much Is True Stats
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