Robin Williams portrays Hunter 'Patch' Adams, a medical student who believes in treating patients with humor and compassion.
Monica Potter plays Carin Fisher, a fellow medical student who supports Patch's unconventional methods and becomes his love interest.
Philip Seymour Hoffman portrays Mitch Roman, a medical student who initially clashes with Patch but later becomes one of his closest friends.
Daniel London takes on the role of Truman Schiff, another medical student who joins Patch in his quest to revolutionize patient care.
Bob Gunton plays Dean Walcott, the traditional dean of the medical school who opposes Patch's unorthodox methods.
Harve Presnell portrays Dean Anderson, the head of the medical school who clashes with Patch but ultimately learns to appreciate his unique approach.
Peter Coyote plays Bill Davis, a doctor who oversees Patch's work and provides guidance and support.
Michael Jeter portrays Rudy, a patient at the hospital who forms a special bond with Patch.
Josef Sommer takes on the role of Dr. Eaton, a senior doctor at the hospital who initially doubts Patch's methods but eventually sees their value.
Irma P. Hall plays Joletta, a nurse at the hospital who admires Patch's compassion towards patients.
Barry Shabaka Henley portrays Emmet, a member of the hospital staff who supports Patch in his efforts to bring joy to patients.
Frances Lee McCain plays Judy, a nurse at the hospital who is inspired by Patch's dedication to his patients.
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