The Hot Zone (TV) Cast
The cast of The Hot Zone. Updated on October 2, 2025.
44 actors
Julianna Margulies
as Lt. Col. Nancy Jaax (6 episodes)

Julianna Margulies portrays Lt. Col. Nancy Jaax in The Hot Zone. Lt. Col. Nancy Jaax is a highly skilled veterinarian and army officer who becomes an integral part of the team fighting against the deadly virus.

Daniel Dae Kim
as Matthew Ryker (6 episodes)

Daniel Dae Kim portrays Matthew Ryker in The Hot Zone. Matthew Ryker is a dedicated and talented scientist who works alongside Lt. Col. Nancy Jaax to analyze and combat the virus.

Noah Emmerich
as Lt. Col. Jerry Jaax (6 episodes)

Noah Emmerich portrays Lt. Col. Jerry Jaax in The Hot Zone. Lt. Col. Jerry Jaax is a military officer and husband to Lt. Col. Nancy Jaax. He plays a crucial role in overseeing the containment efforts during the outbreak.

Tony Goldwyn
as Bruce Ivins (6 episodes)

Tony Goldwyn portrays Bruce Ivins in The Hot Zone. Bruce Ivins is a dedicated microbiologist who becomes involved in the investigation of the virus. His expertise and knowledge prove to be vital in containing the outbreak.

Nick Searcy
as Frank Mays (6 episodes)

Nick Searcy portrays Frank Mays in The Hot Zone. Frank Mays is a dedicated and experienced pilot who plays a critical role in transporting the infected materials.

Liam Cunningham
as Wade Carter (6 episodes)

Liam Cunningham portrays Wade Carter in The Hot Zone. Wade Carter is a courageous and resilient U.S. Army scientist who works closely with Lt. Col. Nancy Jaax and the team to understand and combat the virus.

Dylan Baker
as Ed Copak (6 episodes)

Dylan Baker portrays Ed Copak in The Hot Zone. Ed Copak is a seasoned veterinarian who provides support and expertise in dealing with the infected animals during the outbreak.

James D'Arcy
as Trevor Rhodes (6 episodes)

James D'Arcy portrays Trevor Rhodes in The Hot Zone. Trevor Rhodes is a dedicated and resourceful field investigator who assists Lt. Col. Nancy Jaax and the team in gathering crucial information about the virus.

Mark Kelly
as Bruce Domanski (6 episodes)
Robert Sean Leonard
as Walter Humbolt (6 episodes)
Lenny Platt
as Capt. Kyle Orman (6 episodes)
Topher Grace
as Peter Jahrling (6 episodes)
Paul James
as Ben Gellis (6 episodes)
Robert Wisdom
as Vernon Tucker (6 episodes)
Ian Colletti
as Agent Chris Moore (6 episodes)
Vanessa Matsui
as Jody Hall (6 episodes)
Carlos Gonzalez-Vio
as Simon Kurz (6 episodes)
Rosemary Dunsmore
as Tante de Nancy (1 episode)
Ashton James
as Will (1 episode)
Clark Backo
as Liz Gellis (2 episodes)
Libby Osler
as Reese (3 episodes)
Grace Gummer
as Melinda Danport (4 episodes)
Harry Hamlin
as Tom Brokaw (2 episodes)
Dawn Olivieri
as Dani Toretti (4 episodes)
Denyce Lawton
as Sheila Willis (4 episodes)
Raven Dauda
as Dr. Halstrom (4 episodes)
Sochi Fried
as Janice (3 episodes)
Kristin Booth
as Nancy Haigwood (2 episodes)
Morgan Kelly
as Eric Sykes (5 episodes)
Cody Ray Thompson
as Dale Clemons (1 episode)
Michelle Giroux
as Jean Malecki (1 episode)
Enrico Colantoni
as Rudy Giuliani (1 episode)
Lisa Ryder
as Dr. Marci Layton (1 episode)
Conrad Coates
as Col. Marlon Charles (2 episodes)
William Poulin
as Quinton (2 episodes)
Richard Waugh
as Scott Parrish (2 episodes)
Tony Craig
as Joe Curseen (1 episode)
Ayesha Mansur Gonsalves
as Dr. Adya Livingston (3 episodes)
Justin Mader
as Steven Hatfill (2 episodes)
Martin Happer
as Thomas Ivins (2 episodes)
Jana Peck
as Bruce's Mother (1 episode)
Chelsea Preston
as Mara Linscott (1 episode)
Rob Stewart
as General Dwyer (2 episodes)
Sarah Allen
as Dawn (1 episode)
For the best insights and data about the TV show The Hot Zone, visit our main The Hot Zone page.