John Candy plays Frank Dooley, a down-on-his-luck ex-cop who teams up with Norman Kane to work as security guards.
Eugene Levy portrays Norman Kane, a lawyer who partners with Frank Dooley in their new security guard job.
Robert Loggia takes on the role of Michael Carlino, a mob boss who becomes a central figure in the chaotic events involving Frank and Norman.
Kenneth McMillan plays Captain Clarence O'Connell, a police officer involved in the unfolding events surrounding Frank and Norman.
Meg Ryan portrays Maggie Cavanaugh, a key character whose interactions with Frank and Norman add to the film's comedic moments.
Brion James embodies the character Anthony Lazarus, a menacing presence that complicates the lives of the main characters.
Jonathan Banks takes on the role of Clyde Klepper, a supporting character who crosses paths with Frank and Norman during their adventures.
Don Stroud portrays Sergeant Rizzo, a law enforcement officer who becomes involved in the chaos brought about by Frank and Norman.
Larry Hankin plays Kokolovitch, a character whose interactions with the main duo contribute to the comedic tone of the film.
Steve Railsback embodies The Cowboy, a character who plays a part in the unpredictable events experienced by Frank and Norman.
Robert Burgos portrays Mel Nedler, a character who adds to the mix of personalities encountered by Frank and Norman throughout the film.
Tony Burton takes on the role of Cappy, a character who interacts with the main duo in the midst of their comedic escapades.
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