Graham Crowden plays Professor Millar, the rebellious and outspoken head of Britannia Hospital who becomes entangled in a chaotic series of events.
Leonard Rossiter portrays Vincent Potter, the unscrupulous and ambitious administrator at Britannia Hospital, whose actions drive parts of the plot.
Malcolm McDowell plays Mick Travis, a journalist who infiltrates the hospital and becomes a central figure in exposing its darker aspects.
Joan Plowright portrays Phyllis Grimshaw, a compassionate nurse at Britannia Hospital who tries to navigate the chaos and dysfunction around her.
Mark Hamill appears as Red: The Media, a manipulative and sensationalist reporter who exploits the hospital's troubles for his own gain.
Jill Bennett plays Dr. MacMillan, a senior physician at Britannia Hospital who struggles with the ethical dilemmas posed by the institution's practices.
Brian Pettifer portrays Biles, a troubled patient at Britannia Hospital whose journey reflects the darker side of the healthcare system.
John Moffatt plays Greville Figg, a pompous and self-important government official whose visit to the hospital adds a satirical element to the plot.
Fulton Mackay portrays Chief Superintendant Johns, a no-nonsense police officer who gets involved in the chaotic events unfolding at Britannia Hospital.
Robin Askwith plays Ben Keating, a young doctor at Britannia Hospital who grapples with the moral challenges presented by the institution's practices.
Barbara Hicks portrays Miss Tinker, a quirky and eccentric staff member at Britannia Hospital who adds humor to the story.
Peter Jeffrey appears as Sir Geoffrey, a high-ranking official involved in the management of Britannia Hospital, whose decisions impact the characters' fates.
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