Giselle Eisenberg
as Anna-Kat Otto (13 episodes)
Giselle Eisenberg portrays Anna-Kat Otto, Katie and Greg's middle child, in American Housewife. Anna-Kat is a precocious and intelligent young girl who faces various challenges, including her struggle with Obsessive-Compulsive Disorder (OCD). Eisenberg's performance adds depth and authenticity to Anna-Kat's character, shedding light on the issues faced by children with OCD.