Kevin Kline portrays Dave Kovic, a lookalike of President Bill Mitchell who is hired to impersonate him.
Sigourney Weaver plays Ellen Mitchell, the First Lady who becomes closer to Dave as he takes on the role of her husband.
Frank Langella embodies Bob Alexander, the Chief of Staff who has his own agendas and clashes with Dave.
Kevin Dunn takes on the role of Alan Reed, a Secret Service agent who discovers Dave's impersonation scheme.
Ving Rhames portrays Duane Stevenson, a Secret Service agent who becomes involved in Dave's plan.
Ben Kingsley appears as Vice-President Nance, who has a significant role in the political maneuvers within the film.
Charles Grodin plays Murray Blum, Dave's friend and an accountant who helps him navigate the presidential duties.
Faith Prince is Alice, who works for Dave and supports him during his unexpected presidency.
Laura Linney takes on the role of Randi, a colleague of Dave who becomes suspicious of his behavior.
Bonnie Hunt appears as the White House Tour Guide, providing some comedic relief in the film.
Parley Baer plays the Senate Majority Leader, a political figure who interacts with Dave during his time in office.
Stefan Gierasch portrays the House Majority Leader, another political figure affected by Dave's presidency.
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