Richard Gere plays Richard 'Dixie' Dwyer, a musician and cornet player who gets involved in the world of organized crime.
Gregory Hines portrays Delbert 'Sandman' Williams, a talented tap dancer who performs at the Cotton Club.
Diane Lane takes on the role of Vera Cicero, a beautiful and aspiring socialite who becomes involved with the club.
Lonette McKee plays Lila Rose Oliver, a talented singer who performs at the Cotton Club and becomes entangled in a love triangle.
Bob Hoskins portrays Owney Madden, a powerful and influential mobster who runs the Cotton Club.
James Remar is Dutch Schultz, a ruthless and violent gangster who clashes with other mobsters in his quest for power.
Nicolas Cage portrays Vincent Dwyer, the troubled brother of Richard 'Dixie' Dwyer who gets caught up in criminal activities.
Allen Garfield plays Otto 'Abbadabba' Berman, a Jewish gangster and accountant who works for the mob.
Fred Gwynne portrays Frenchy Demange, a nightclub owner and associate of the mob who deals in illegal activities.
Gwen Verdon is Tish Dwyer, the mother of Richard 'Dixie' Dwyer who is supportive of her son's musical career.
Lisa Jane Persky plays Frances Flegenheimer, the wife of Dutch Schultz who becomes involved in his criminal enterprises.
Maurice Hines portrays Clay Williams, the brother of Delbert 'Sandman' Williams who also performs as a tap dancer at the Cotton Club.
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