Goldie Hawn portrays Elise Elliot Atchison, a successful actress struggling with aging in Hollywood and her ex-husband's affair with a younger woman.
Bette Midler plays Brenda Morelli Cushman, a middle-aged actress and former starlet who is bitter about her ex-husband leaving her for a younger woman.
Diane Keaton is Annie MacDuggan Paradis, a woman facing an empty nest and wondering about the worth of her life as her husband decides to leave her for a younger woman.
Maggie Smith takes on the role of Gunilla Garson Goldberg, a wealthy and refined woman who was also betrayed by her husband in favor of a younger woman.
Sarah Jessica Parker portrays Shelly Stewart, a young girlfriend of one of the ex-husbands who is naive and somewhat gullible.
Dan Hedaya plays Morton Cushman, Brenda's ex-husband who left her for a much younger woman.
Stockard Channing is Cynthia Swann Griffin, a plastic surgeon who helps women improve their appearances and boasts about her husband leaving her for a younger woman.
Victor Garber portrays Bill Atchison, Elise's ex-husband who left her for a younger woman and struggles to have a relationship with his daughter.
Stephen Collins plays Aaron Paradis, Annie's husband who decides to leave her for a younger woman due to his midlife crisis.
Elizabeth Berkley is Phoebe LaVelle, a young actress and singer who becomes the obsession of one of the ex-husbands, leading to chaos.
Marcia Gay Harden takes on the role of Dr. Leslie Rosen, a therapist who helps one of the characters work through her relationship issues.
Bronson Pinchot plays Duarto Feliz, a flamboyant interior designer who provides support and comic relief to the main characters.
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