Robert Hays portrays the protagonist Ted Striker, a troubled former Air Force pilot who must overcome his fears and save the day.
Julie Hagerty plays Elaine Dickinson, a flight attendant and Ted Striker's love interest who shows resilience in the face of chaos.
Leslie Nielsen is Dr. Rumack, a deadpan and clueless doctor onboard the flight who adds to the comedic chaos with his obliviousness.
Kareem Abdul-Jabbar takes on the role of Roger Murdock, an NBA co-pilot hilariously mistaken for the basketball legend during the flight.
Lloyd Bridges portrays Steve McCroskey, the harried and overworked air traffic controller who tries to manage the escalating crisis with comedic results.
Peter Graves appears as Captain Clarence Oveur, the pilot with a dry sense of humor who faces absurd challenges while flying the troubled plane.
Lorna Patterson plays Randy, a flight attendant who deals with the frantic and bizarre situations unfolding on the troubled aircraft.
Robert Stack embodies the character Captain Rex Kramer, a no-nonsense and capable pilot who tries to assist in resolving the crisis onboard.
Jim Abrahams cameos as Religious Zealot #6, adding a touch of humor and absurdity to the passengers onboard the chaotic flight.
Jonathan Banks appears as Gunderson, a passenger caught up in the mayhem on the plane, providing comedic relief in the face of adversity.
Stephen Stucker portrays Johnny Henshaw-Jacobs, the flamboyant and energetic air traffic controller who adds to the chaos with his quirky behavior.
Frank Ashmore plays Victor Basta, a supporting character who contributes to the absurdity and humor of the overall storyline.
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