Michael Keaton plays Henry Hackett, the driven and dedicated editor of a New York tabloid.
Robert Duvall portrays Bernie White, the seasoned managing editor of the newspaper.
Glenn Close takes on the role of Alicia Clark, the publisher of the newspaper facing a major decision.
Marisa Tomei is Martha Hackett, Henry's supportive and understanding wife.
Randy Quaid plays Michael McDougal, a volatile columnist at the newspaper.
Jason Alexander portrays Marion Sandusky, a quirky journalist at the newspaper.
Catherine O'Hara takes on the role of Susan, a member of the newspaper staff.
Jason Robards portrays Graham Keighley, the newspaper's intimidating owner.
Siobhan Fallon Hogan plays Lisa, a resourceful member of the newspaper team.
Jill Hennessy is Deanne White, Bernie's supportive wife who faces her own challenges.
Spalding Gray portrays Paul Bladden, a top editor at the newspaper.
Lynne Thigpen plays Janet, a no-nonsense member of the newspaper's staff.
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