Regina Hall plays Ryan Pierce, a successful author, and self-help guru who appears to have a perfect life.
Queen Latifah portrays Sasha Franklin, a journalist and gossip columnist dealing with professional setbacks.
Jada Pinkett Smith takes on the role of Lisa Cooper, a nurse and single mother who has put her wild past behind her.
Tiffany Haddish plays Dina, an outrageous and fun-loving member of the group who adds spontaneity to their trip.
Larenz Tate portrays Julian Stevens, an old college friend of the group who reconnects with them during the festival.
Mike Colter plays Stewart Pierce, Ryan's husband, who has his own secrets and struggles.
Kate Walsh portrays Elizabeth Davelli, a friend of the group who stirs up drama during their trip.
Kofi Siriboe plays Malik, a charming young man who catches the eye of one of the friends during the festival.
Morris Chestnut makes a cameo appearance as himself, a famous actor and heartthrob at the Essence Music Festival.
Deborah Ayorinde portrays Simone, another friend of the group who joins them in New Orleans.
Tonea Stewart plays Aunt Marian, a wise and supportive figure in the lives of the four friends.
Lara Grice portrays Bethany, a character who interacts with the group during their time in New Orleans.
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