Californication

David Duchovny portrays Hank Moody, a talented but self-destructive writer. Hank is known for his womanizing tendencies, substance abuse issues, and his struggle to balance his personal life with his writing career.

Natascha McElhone plays the role of Karen van der Beek, Hank's on-again, off-again girlfriend and the mother of his daughter Becca. Karen is a strong and independent woman who constantly finds herself torn between her love for Hank and her desire for stability.

Evan Handler portrays Charlie Runkle, Hank's best friend and agent. Charlie is a well-meaning but often bumbling character who struggles with his own personal and professional shortcomings.

Pamela Adlon plays Marcy Runkle, Charlie's estranged wife. Marcy is a quirky and unconventional woman who constantly finds herself entangled in chaotic situations, both in her personal and professional life.

Madeleine Martin portrays two characters in the show: Becca Moody, Hank and Karen's daughter who is wise beyond her years, and Rebecca Moody, Becca's rebellious and troubled cousin.

Madeline Zima plays the role of Mia Lewis, a teenage girl who becomes involved with Hank and causes significant turmoil in his life. Mia seduces Hank and later publishes his novel without his knowledge, leading to a series of complicated events.

Callum Keith Rennie portrays Lew Ashby, a charismatic and enigmatic rock and roll legend who becomes a close friend and mentor to Hank. Lew's presence in Hank's life has a profound impact on his personal and creative journey.