The Drew Barrymore Show (TV) Cast
The cast of The Drew Barrymore Show. Updated on September 15, 2025.
112 actors
Drew Barrymore
as Self - Host (367 episodes)

Drew Barrymore hosts the show, bringing her experience as an actress and producer to the talk show format.

Ross Mathews
as Self - Co-Host (86 episodes)

Ross Mathews frequently appears as a co-host, known for his vibrant personality and previous television appearances.

Adam Sandler
as Self (1 episode)

Adam Sandler makes guest appearances on the show, sharing anecdotes from his career in comedy and acting.

Gabrielle Union
as Self (1 episode)

Gabrielle Union joins the show as a guest, offering insights into her experiences as an actress and author.

Christian Siriano
as Self (1 episode)

Christian Siriano appears on the show, discussing his work as a fashion designer.

Tyra Banks
as Self (1 episode)

Tyra Banks guests on the show, known for her modeling career and work as a television producer.

Billy Porter
as Self (1 episode)

Billy Porter, celebrated for his work in theater and television, shares his journey and projects on the show.

Billy Eichner
as Self (1 episode)

Billy Eichner joins the show, bringing his humor and perspective as a comedian and actor.

Derrick Barnes
as Self (1 episode)

Derrick Barnes appears as a guest, known for his work as a children's book author.

Jennifer Aniston
as Self (1 episode)

Jennifer Aniston appears on the show, discussing her extensive career in television and film.

Wayne Brady
as Self (1 episode)

Wayne Brady, known for his versatility in comedy and acting, guests on the show.

Mariska Hargitay
as Self (1 episode)
Ali Wentworth
as Self (1 episode)
Charlize Theron
as Self (1 episode)
Paris Hilton
as Self (1 episode)
José Andrés Puerta
as Self (1 episode)
Hugh Grant
as Self (1 episode)
Olivia Rodrigo
as Self (1 episode)
Sophia Bush
as Self (1 episode)
Nicole Lapin
as Self (1 episode)
Sabrina Carpenter
as Self (1 episode)
Carla Lalli Music
as Self (1 episode)
Scarlett Johansson
as Self (1 episode)
Molly Shannon
as Self (1 episode)
Michael Vartan
as Self (1 episode)
Billie Eilish
as Self (1 episode)
Cedric the Entertainer
as Self (1 episode)
Kevin Frazier
as Self (1 episode)
Awkwafina
as Self (1 episode)
Fat Joe
as Self (1 episode)
Fran Drescher
as Self (1 episode)
Benito Skinner
as Self (1 episode)
Reese Witherspoon
as Self (2 episodes)
Tiki Barber
as Self (1 episode)
Jenny Mollen
as Self (1 episode)
Lucy Liu
as Self (2 episodes)
Eddie Murphy
as Self (1 episode)
Courteney Cox
as Self (1 episode)
Neve Campbell
as Self (1 episode)
David Arquette
as Self (2 episodes)
Kathryn Hahn
as Self (1 episode)
Jane Levy
as Self (1 episode)
Amy Schumer
as Self (1 episode)
Violet Young
as Self (1 episode)
Keanu Reeves
as Self (1 episode)
Aubrey Plaza
as Self (1 episode)
Chloë Grace Moretz
as Self (1 episode)
Andra Day
as Self (1 episode)
Erin Napier
as Self (1 episode)
Ben Napier
as Self (1 episode)
Ben Platt
as Self (1 episode)
Samantha Bee
as Self (1 episode)
Kristen Wiig
as Self (1 episode)
Jamie Dornan
as Self (1 episode)
Annie Mumolo
as Self (1 episode)
Cameron Diaz
as Self (4 episodes)
Steven Spielberg
as Self (1 episode)
David Letterman
as Self (1 episode)
Jimmy Fallon
as Self (1 episode)
Keith Morrison
as Self (1 episode)
Savannah Guthrie
as Self (1 episode)
Chelsea Handler
as Self (1 episode)
Jason Biggs
as Self (2 episodes)
Rita Ora
as Self (1 episode)
Kat Dennings
as Self (1 episode)
Garcelle Beauvais
as Self (1 episode)
Jennifer Love Hewitt
as Self (1 episode)
Abigail Cowen
as Self (1 episode)
Regina Hall
as Self (1 episode)
Lana Condor
as Self (1 episode)
Jill Kargman
as Self (1 episode)
Priyanka Chopra Jonas
as Self (1 episode)
Lionel Richie
as Self (1 episode)
Dakota Johnson
as Self (1 episode)
Jenna Ortega
as Self (1 episode)
Ralph Macchio
as Self (1 episode)
Gwyneth Paltrow
as Self (2 episodes)
Regé-Jean Page
as Self (1 episode)
Phoebe Dynevor
as Self (1 episode)
Ellie Kemper
as Self (3 episodes)
Suzanne Somers
as Self (1 episode)
Jet Tila
as Self (1 episode)
Iris Apatow
as Self (1 episode)
John Cho
as Self (1 episode)
Nischelle Turner
as Self (2 episodes)
Lea Michele
as Self (1 episode)
Millie Bobby Brown
as Self (1 episode)
Eva Longoria
as Self (1 episode)
Damson Idris
as Self (1 episode)
Giada De Laurentiis
as Self (1 episode)
Dylan Mulvaney
as Self (1 episode)
Lewis Howes
as Self (1 episode)
Shania Twain
as (1 episode)
Julia Fox
as (1 episode)
Bob Odenkirk
as Self - Guest (1 episode)
Nicole Avant
as (1 episode)
Cleo Wade
as (1 episode)
Reggie Watts
as (1 episode)
Yara Shahidi
as (1 episode)
Mikel Welch
as (1 episode)
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