Cast of The Drew Barrymore Show

Drew Barrymore hosts the show, bringing her experience as an actress and producer to the talk show format.

Ross Mathews frequently appears as a co-host, known for his vibrant personality and previous television appearances.

Adam Sandler makes guest appearances on the show, sharing anecdotes from his career in comedy and acting.

Gabrielle Union joins the show as a guest, offering insights into her experiences as an actress and author.

Christian Siriano appears on the show, discussing his work as a fashion designer.

Tyra Banks guests on the show, known for her modeling career and work as a television producer.

Billy Porter, celebrated for his work in theater and television, shares his journey and projects on the show.

Billy Eichner joins the show, bringing his humor and perspective as a comedian and actor.

Derrick Barnes appears as a guest, known for his work as a children's book author.

Jennifer Aniston appears on the show, discussing her extensive career in television and film.

Wayne Brady, known for his versatility in comedy and acting, guests on the show.