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Desus & Mero
Cast
107 cast members · 97 with popularity data
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Full Cast
Sorted by Buzz Score · May 4, 2026
1
Charlize Theron
Self - Illustrious Guest
· 1 eps
35.6
#33 overall
2
Zendaya
Self
· 1 eps
24.2
#45 overall
3
Yahya Abdul-Mateen II
Self - Illustrious Guest
· 1 eps
18.0
#68 overall
4
Barack Obama
Self - Illustrious Guest
· 1 eps
14.9
#93 overall
5
Diplo
Self
· 1 eps
11.5
#153 overall
6
Joe Biden
Self - Illustrious Guest
· 1 eps
11.0
#165 overall
7
Seth Rogen
Self - Illustrious Guest
· 2 eps
10.5
#179 overall
8
Ben Stiller
Self - Illustrious Guest
· 1 eps
9.5
#211 overall
9
Jordan Peele
Self - Illustrious Guest
· 1 eps
6.6
#438 overall
10
Carmelo Anthony
Self - Illustrious Guest
· 1 eps
6.1
#491 overall
11
Kamala Harris
Self - Illustrious Guest
· 1 eps
5.4
#637 overall
12
Spike Lee
Self - Illustrious Guest
· 1 eps
4.9
#741 overall
13
Rashida Jones
Self - Illustrious Guest
· 1 eps
4.8
#757 overall
14
Ethan Hawke
Self - Illustrious Guest
· 1 eps
4.5
#835 overall
15
Usain Bolt
Self - Illustrious Guest
· 1 eps
4.5
#839 overall
16
Eddie Murphy
Self
· 1 eps
4.4
#888 overall
17
Glenn Close
Self
· 1 eps
4.2
#934 overall
18
Chris Rock
Self - Illustrious Guest
· 1 eps
4.0
#1,019 overall
19
Amy Poehler
Self - Illustrious Guest
· 1 eps
4.0
#1,028 overall
20
Judd Apatow
Self - Illustrious Guest
· 1 eps
3.7
#1,157 overall
21
Demi Lovato
Self
· 1 eps
3.6
#1,233 overall
22
Janelle Monáe
Self - Illustrious Guest
· 1 eps
3.5
#1,325 overall
23
Dwyane Wade
Self - Illustrious Guest
· 1 eps
3.5
#1,330 overall
24
Anna Kendrick
Self - Illustrious Guest
· 1 eps
3.4
#1,347 overall
25
Penn Badgley
Self - Illustrious Guest
· 1 eps
3.4
#1,351 overall
26
Lupita Nyong'o
Self - Illustrious Guest
· 1 eps
3.2
#1,472 overall
27
Anthony Mackie
Self
· 1 eps
3.2
#1,498 overall
28
RZA
Self - Illustrious Guest
· 1 eps
3.2
#1,529 overall
29
Katie Porter
Self - Illustrious Guest
· 1 eps
3.2
#1,543 overall
30
Jesse Williams
Self - Illustrious Guest
· 1 eps
3.1
#1,604 overall
31
Jon Stewart
Self - Illustrious Guest
· 1 eps
3.0
#1,655 overall
32
Mark Cuban
Self - Illustrious Guest
· 1 eps
2.9
#1,721 overall
33
John Mulaney
Self - Illustrious Guest
· 1 eps
2.9
#1,733 overall
34
Whoopi Goldberg
Self
· 1 eps
2.9
#1,752 overall
35
Gabrielle Union
Self - Illustrious Guest
· 2 eps
2.9
#1,759 overall
36
Spike Jonze
Self - Illustrious Guest
· 1 eps
2.8
#1,842 overall
37
Andy Samberg
Self - Illustrious Guest
· 1 eps
2.8
#1,888 overall
38
LL Cool J
Self - Illustrious Guest
· 1 eps
2.6
#2,006 overall
39
Nick Kroll
Self - Illustrious Guest
· 1 eps
2.5
#2,140 overall
40
Stephen A. Smith
Self - Illustrious Guest
· 1 eps
2.4
#2,252 overall
41
Bill Hader
Self - Illustrious Guest
· 1 eps
2.4
#2,260 overall
42
Tony Hawk
Self - Illustrious Guest
· 1 eps
2.2
#2,553 overall
43
Alicia Keys
Self - Illustrious Guest
· 1 eps
2.2
#2,575 overall
44
John David Washington
Self
· 1 eps
2.0
#2,820 overall
45
Tracee Ellis Ross
Self - Illustrious Guest
· 1 eps
2.0
#2,822 overall
46
Jay Ellis
Self - Illustrious Guest
· 1 eps
2.0
#2,825 overall
47
Phoebe Bridgers
Self
· 1 eps
1.9
#3,013 overall
48
David Letterman
Self - Illustrious Guest
· 1 eps
1.9
#3,158 overall
49
Jason Derulo
Self - Illustrious Guest
· 1 eps
1.8
#3,204 overall
50
Kenan Thompson
Self
· 1 eps
1.8
#3,330 overall
51
Jaden Smith
Self - Illustrious Guest
· 1 eps
1.8
#3,368 overall
52
Cory Booker
Self - Illustrious Guest
· 1 eps
1.7
#3,435 overall
53
Seth Meyers
Self - Illustrious Guest
· 1 eps
1.7
#3,458 overall
54
Delroy Lindo
Self
· 1 eps
1.7
#3,487 overall
55
Don Cheadle
Self - Illustrious Guest
· 2 eps
1.7
#3,591 overall
56
Sheila E.
Self
· 1 eps
1.6
#3,631 overall
57
Lil Nas X
Self - Illustrious Guest
· 1 eps
1.6
#3,747 overall
58
Ludacris
Self
· 1 eps
1.6
#3,755 overall
59
John Legend
Self - Illustrious Guest
· 2 eps
1.5
#3,935 overall
60
Eric André
Self - Illustrious Guest
· 1 eps
1.5
#3,950 overall
61
Anthony Fauci
Self - Illustrious Guest
· 1 eps
1.4
#4,255 overall
62
Kelly Rowland
Self
· 1 eps
1.4
#4,358 overall
63
Ramy Youssef
Self
· 1 eps
1.4
#4,390 overall
64
LaKeith Stanfield
Self - Illustrious Guest
· 1 eps
1.3
#4,591 overall
65
Busta Rhymes
Self
· 1 eps
1.2
#5,089 overall
66
Timbaland
Self - Illustrious Guest
· 1 eps
1.2
#5,216 overall
67
Issa Rae
Self - Illustrious Guest
· 2 eps
1.2
#5,265 overall
68
Missy Elliott
Self - Illustrious Guest
· 1 eps
1.1
#5,524 overall
69
Cori Bush
Self - Illustrious Guest
· 1 eps
0.9
#6,433 overall
70
Billy Porter
Self - Illustrious Guest
· 1 eps
0.9
#6,821 overall
71
Sue Bird
Self - Illustrious Guest
· 1 eps
0.9
#6,823 overall
72
Vince Staples
Self - Illustrious Guest
· 1 eps
0.9
#6,975 overall
73
Swizz Beatz
Self - Illustrious Guest
· 1 eps
0.8
#7,334 overall
74
Killer Mike
Self - Illustrious Guest
· 1 eps
0.8
#7,454 overall
75
Winston Duke
Self - Illustrious Guest
· 1 eps
0.8
#7,468 overall
76
Big Sean
Self - Illustrious Guest
· 1 eps
0.8
#7,553 overall
77
Malcolm Gladwell
Self - Illustrious Guest
· 1 eps
0.8
#7,631 overall
78
Kirsten Gillibrand
Self - Illustrious Guest
· 1 eps
0.8
#7,786 overall
79
Eddie Huang
Self
· 1 eps
0.7
#8,499 overall
80
Stacey Abrams
Self - Illustrious Guest
· 2 eps
0.6
#9,029 overall
81
Maxine Waters
Self - Illustrious Guest
· 1 eps
0.6
#9,221 overall
82
Paul Scheer
Self - Special Appearance
· 1 eps
0.6
#9,293 overall
83
Matt Walsh
Self - Illustrious Guest
· 1 eps
0.6
#9,337 overall
84
J Balvin
Self
· 1 eps
0.6
#9,967 overall
85
2 Chainz
Self - Illustrious Guest
· 1 eps
0.6
#10,011 overall
86
Darrell Wallace, Jr.
Self - Illustrious Guest
· 1 eps
0.5
#10,577 overall
87
Andra Day
Self
· 1 eps
0.4
#11,763 overall
88
Ava DuVernay
Self - Illustrious Guest
· 1 eps
0.4
#13,573 overall
89
Jamaal Bowman
Self - Illustrious Guest
· 1 eps
0.3
#14,875 overall
90
Jazmine Sullivan
Self
· 1 eps
0.2
#17,774 overall
91
Sarah Cooper
Self - Illustrious Guest
· 1 eps
0.2
#18,235 overall
92
The Kid Mero
Self - Host
· 180 eps
0.2
#19,583 overall
93
A$AP Ferg
Self
· 1 eps
0.2
#20,120 overall
94
24kGoldn
Self
· 1 eps
0.1
#22,902 overall
95
Travis "Taco" Bennett
Self
· 1 eps
0.1
#23,593 overall
96
Alison Roman
Self - Illustrious Guest
· 1 eps
0.1
#30,969 overall
97
Travon Free
Self
· 1 eps
0.0
#50,649 overall
98
Desus Nice
Self - Host
· 180 eps
—
99
Jaime Harrison
Self - Illustrious Guest
· 1 eps
—
100
Freddie Gibbs
Self
· 2 eps
—
Load full cast (107)
Desus & Mero Stats
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