Desus & Mero (TV) Cast
The cast of Desus & Mero. Updated on September 16, 2025.
107 actors
Desus Nice
as Self - Host (180 episodes)

Desus Nice hosts the show, delivering sharp wit and quick humor as a key voice.

The Kid Mero
as Self - Host (180 episodes)

The Kid Mero is the co-host, known for his unique comedic style and lively discussions.

Amy Poehler
as Self - Illustrious Guest (1 episode)

Amy Poehler is an illustrious guest on the show.

Vince Staples
as Self - Illustrious Guest (1 episode)

Vince Staples joins as an illustrious guest, bringing his perspective to the conversation.

Ben Stiller
as Self - Illustrious Guest (1 episode)

Ben Stiller appears as an illustrious guest, adding his own insights and humor.

2 Chainz
as Self - Illustrious Guest (1 episode)

2 Chainz is an illustrious guest on the show.

Lupita Nyong'o
as Self - Illustrious Guest (1 episode)

Lupita Nyong'o visits as an illustrious guest, sharing her experiences and views.

Winston Duke
as Self - Illustrious Guest (1 episode)

Winston Duke features as an illustrious guest.

Kirsten Gillibrand
as Self - Illustrious Guest (1 episode)

Kirsten Gillibrand makes an appearance as an illustrious guest, contributing to discussions on various topics.

Carmelo Anthony
as Self - Illustrious Guest (1 episode)

Carmelo Anthony steps in as an illustrious guest.

Jordan Peele
as Self - Illustrious Guest (1 episode)

Jordan Peele is an illustrious guest, known for his creative work and contributions.

Anna Kendrick
as Self - Illustrious Guest (1 episode)

Anna Kendrick is an illustrious guest on the show.

Cory Booker
as Self - Illustrious Guest (1 episode)
Lil Nas X
as Self - Illustrious Guest (1 episode)
Paul Scheer
as Self - Special Appearance (1 episode)
Charlize Theron
as Self - Illustrious Guest (1 episode)
Bill Hader
as Self - Illustrious Guest (1 episode)
Ava DuVernay
as Self - Illustrious Guest (1 episode)
Spike Lee
as Self - Illustrious Guest (1 episode)
Matt Walsh
as Self - Illustrious Guest (1 episode)
David Letterman
as Self - Illustrious Guest (1 episode)
Penn Badgley
as Self - Illustrious Guest (1 episode)
LaKeith Stanfield
as Self - Illustrious Guest (1 episode)
Kamala Harris
as Self - Illustrious Guest (1 episode)
Maxine Waters
as Self - Illustrious Guest (1 episode)
John Mulaney
as Self - Illustrious Guest (1 episode)
Barack Obama
as Self - Illustrious Guest (1 episode)
Killer Mike
as Self - Illustrious Guest (1 episode)
Missy Elliott
as Self - Illustrious Guest (1 episode)
Busta Rhymes
as Self (1 episode)
Diplo
as Self (1 episode)
Sheila E.
as Self (1 episode)
A$AP Ferg
as Self (1 episode)
Chris Rock
as Self - Illustrious Guest (1 episode)
RZA
as Self - Illustrious Guest (1 episode)
Sarah Cooper
as Self - Illustrious Guest (1 episode)
Yahya Abdul-Mateen II
as Self - Illustrious Guest (1 episode)
Ethan Hawke
as Self - Illustrious Guest (1 episode)
Jason Derulo
as Self - Illustrious Guest (1 episode)
Swizz Beatz
as Self - Illustrious Guest (1 episode)
Timbaland
as Self - Illustrious Guest (1 episode)
LL Cool J
as Self - Illustrious Guest (1 episode)
Tony Hawk
as Self - Illustrious Guest (1 episode)
Big Sean
as Self - Illustrious Guest (1 episode)
Janelle Monáe
as Self - Illustrious Guest (1 episode)
Jaden Smith
as Self - Illustrious Guest (1 episode)
Jaime Harrison
as Self - Illustrious Guest (1 episode)
Sue Bird
as Self - Illustrious Guest (1 episode)
Cori Bush
as Self - Illustrious Guest (1 episode)
Usain Bolt
as Self - Illustrious Guest (1 episode)
Stephen A. Smith
as Self - Illustrious Guest (1 episode)
Andy Samberg
as Self - Illustrious Guest (1 episode)
Eric André
as Self - Illustrious Guest (1 episode)
Judd Apatow
as Self - Illustrious Guest (1 episode)
Bubba Wallace
as Self - Illustrious Guest (1 episode)
Jon Stewart
as Self - Illustrious Guest (1 episode)
Jamaal Bowman
as Self - Illustrious Guest (1 episode)
Jesse Williams
as Self - Illustrious Guest (1 episode)
Dwyane Wade
as Self - Illustrious Guest (1 episode)
Katie Porter
as Self - Illustrious Guest (1 episode)
Billy Porter
as Self - Illustrious Guest (1 episode)
Spike Jonze
as Self - Illustrious Guest (1 episode)
Rashida Jones
as Self - Illustrious Guest (1 episode)
Jay Ellis
as Self - Illustrious Guest (1 episode)
Alicia Keys
as Self - Illustrious Guest (1 episode)
Joe Biden
as Self - Illustrious Guest (1 episode)
Mark Cuban
as Self - Illustrious Guest (1 episode)
Tracee Ellis Ross
as Self - Illustrious Guest (1 episode)
Gabrielle Union
as Self - Illustrious Guest (2 episodes)
Malcolm Gladwell
as Self - Illustrious Guest (1 episode)
John David Washington
as Self (1 episode)
Stacey Abrams
as Self - Illustrious Guest (2 episodes)
Seth Rogen
as Self - Illustrious Guest (2 episodes)
Alison Roman
as Self - Illustrious Guest (1 episode)
Anthony Fauci
as Self - Illustrious Guest (1 episode)
Issa Rae
as Self - Illustrious Guest (2 episodes)
Demi Lovato
as Self (1 episode)
Don Cheadle
as Self - Illustrious Guest (2 episodes)
Seth Meyers
as Self - Illustrious Guest (1 episode)
John Legend
as Self - Illustrious Guest (2 episodes)
Nick Kroll
as Self - Illustrious Guest (1 episode)
J Balvin
as Self (1 episode)
Andra Day
as Self (1 episode)
Glenn Close
as Self (1 episode)
Kenan Thompson
as Self (1 episode)
24kGoldn
as Self (1 episode)
Eddie Murphy
as Self (1 episode)
Phoebe Bridgers
as Self (1 episode)
Eddie Huang
as Self (1 episode)
Delroy Lindo
as Self (1 episode)
Ramy Youssef
as Self (1 episode)
Travis "Taco" Bennett
as Self (1 episode)
Kelly Rowland
as Self (1 episode)
Ludacris
as Self (1 episode)
Anthony Mackie
as Self (1 episode)
Zendaya
as Self (1 episode)
Whoopi Goldberg
as Self (1 episode)
Jazmine Sullivan
as Self (1 episode)
Freddie Gibbs
as Self (1 episode)
Travon Free
as Self (1 episode)
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