Masters of Sex (TV) Cast Popularity
The cast of Masters of Sex including daily popularity data. Updated on May 16, 2025.
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525 total actors
Michael Sheen
as William Masters (46 episodes)

Michael Sheen portrays the character of Dr. William Masters, a renowned fertility expert and a pioneer in the study of human sexuality.

#3
Most popular actor on Masters of Sex
4,383 Wikipedia views yesterday
Lizzy Caplan
as Virginia Johnson (46 episodes)

Lizzy Caplan plays the role of Virginia Johnson, Dr. Masters' assistant and eventual research partner. Johnson becomes an influential figure in the field of sexual research.

#4
Most popular actor on Masters of Sex
3,290 Wikipedia views yesterday
Caitlin FitzGerald
as Libby Masters (46 episodes)

Caitlin FitzGerald portrays the character of Libby Masters, Dr. Masters' wife. Libby struggles with her own desires and the challenges of their unconventional marriage.

#54
Most popular actor on Masters of Sex
694 Wikipedia views yesterday
Annaleigh Ashford
as Betty DiMello (37 episodes)

Annaleigh Ashford plays the role of Betty DiMello, a sex worker who becomes an integral part of Dr. Masters and Virginia's research team.

#18
Most popular actor on Masters of Sex
2,070 Wikipedia views yesterday
Nicholas D'Agosto
as Dr. Ethan Haas (14 episodes)

Nicholas D'Agosto portrays the character of Dr. Ethan Haas, a young and ambitious doctor who joins Dr. Masters' team and becomes involved in their controversial research.

#19
Most popular actor on Masters of Sex
2,060 Wikipedia views yesterday
Teddy Sears
as Dr. Austin Langham (29 episodes)

Teddy Sears plays the role of Dr. Austin Langham, another member of Dr. Masters' team who assists in their groundbreaking research.

#94
Most popular actor on Masters of Sex
238 Wikipedia views yesterday
Roslyn Ruff
as Josephine May (1 episode)

Roslyn Ruff portrays the character of Josephine May, a patient of Dr. Masters who becomes an active participant in the research studies.

Margo Martindale
as Miss Horchow (1 episode)

Margo Martindale plays the role of Miss Horchow, the head of the university library where Dr. Masters and Virginia conduct much of their research.

#34
Most popular actor on Masters of Sex
1,193 Wikipedia views yesterday
Steve Rosen
as Ernie Turk (1 episode)
Johanna Day
as Advisor (1 episode)
#163
Most popular actor on Masters of Sex
25 Wikipedia views yesterday
Mary Jo McConnell
as Desk Nurse (1 episode)
Jeffrey C. Hawkins
as OR Doctor #1 (1 episode)
Linda Marie Larson
as Lois Tupps (1 episode)
Danae Nason
as Assisting Nurse #1 (1 episode)
Mark Rosing
as Anesthesiologist (1 episode)
Phil McGlaston
as Worker (1 episode)
Duncan Bindbeutel
as Doctor at Party (uncredited) (1 episode)
Roy Pollack
as Upscale Party Goer (uncredited) (1 episode)
Elysia Richards
as Nurse (uncredited) (1 episode)
Tanya Wheelock
as College Student (uncredited) (1 episode)
Matthew Dean Wood
as Party Guest (uncredited) (1 episode)
Elizabeth Dennehy
as (1 episode)
#91
Most popular actor on Masters of Sex
245 Wikipedia views yesterday
April Parker Jones
as Mrs. Katcher (1 episode)
#132
Most popular actor on Masters of Sex
83 Wikipedia views yesterday
Ruby Lewis
as Connie (1 episode)
#175
Most popular actor on Masters of Sex
14 Wikipedia views yesterday
Kristin Slaysman
as Bernadette (1 episode)
Susan-Kate Heaney
as Shirley (1 episode)
Khali Macintyre
as Claire (1 episode)
Debbie Jaffe
as Nurse Grand (1 episode)
Clark Moore
as Officer Burt (1 episode)
#160
Most popular actor on Masters of Sex
27 Wikipedia views yesterday
Doug Hurley
as John (uncredited) (1 episode)
#144
Most popular actor on Masters of Sex
52 Wikipedia views yesterday
Mae Whitman
as Patient (1 episode)
#9
Most popular actor on Masters of Sex
2,788 Wikipedia views yesterday
Lauren Weedman
as Quadruplets' Mother (1 episode)
#64
Most popular actor on Masters of Sex
457 Wikipedia views yesterday
Nicholle Tom
as Maureen (2 episodes)
#50
Most popular actor on Masters of Sex
735 Wikipedia views yesterday
Sara Rae Foster
as Dottie (2 episodes)
Ellen Wroe
as Ginger (2 episodes)
Bobby Campo
as Carl (1 episode)
#33
Most popular actor on Masters of Sex
1,251 Wikipedia views yesterday
David Ury
as (1 episode)
#156
Most popular actor on Masters of Sex
32 Wikipedia views yesterday
Simone Carter
as Arda (1 episode)
Clark Freeman
as Operating Doctor #1 (1 episode)
Natasha Sims
as Operating Nurse (1 episode)
Ori Kalmus
as Reporter (1 episode)
Casey Dolkas
as Photographer (1 episode)
Cleo Fraser
as Vivian Scully (1 episode)
Adam Maurer
as Med Student (uncredited) (1 episode)
Barrett Perlman
as Prostitute (uncredited) (1 episode)
Evie Ryland
as Nursery Visitor (uncredited) (1 episode)
Leah Shaw
as Prostitute (uncredited) (1 episode)
Michael Mantell
as Byron (1 episode)
Martha Hackett
as Shirley (1 episode)
#147
Most popular actor on Masters of Sex
46 Wikipedia views yesterday
William Nicol
as Assistant Doctor (1 episode)
Emily Bridges
as Velma (1 episode)
Dean Chekvala
as Mr. Zelinsky (1 episode)
Kira Sternbach
as Marjorie (1 episode)
Gabe O'Mara
as Daniel Zelinsky (1 episode)
Monica Hewes
as Sophia Zelinsky (1 episode)
Michael Tower
as Doug (1 episode)
Carolyn Crotty
as Marilyn (1 episode)
Jed Sura
as Assistant Doctor (1 episode)
Tony Robinette
as Nerdy Man (1 episode)
Charlotte Chanler
as Woman (1 episode)
Chris Degner
as Working Class Man (1 episode)
Sarah Allyn Bauer
as Young Woman (1 episode)
Faleena Hopkins
as Young Estabrooks (1 episode)
Christian O'Brien
as Guest (uncredited) (1 episode)
#190
Most popular actor on Masters of Sex
3 Wikipedia views yesterday
Jorie Stern
as Nurse (uncredited) (4 episodes)
Joseph Lyle Taylor
as Stan (1 episode)
Kyle Jones
as Glenn (1 episode)
Emily Davenport
as Patty (1 episode)
Romina Bovolini
as F-102 (1 episode)
Cheryl Bricker
as Subject 096 (1 episode)
Mike Peebler
as Anesthesiologist (1 episode)
Shaun Rylee
as Scully Family Friend (uncredited) (1 episode)
Barry Bostwick
as Morris (1 episode)
#51
Most popular actor on Masters of Sex
735 Wikipedia views yesterday
Ann Cusack
as Harriet (1 episode)
#45
Most popular actor on Masters of Sex
800 Wikipedia views yesterday
Caroline Lagerfelt
as Barb (1 episode)
#108
Most popular actor on Masters of Sex
164 Wikipedia views yesterday
Leah Costello
as Louise (1 episode)
Rachel Kimsey
as Nessie Lawson (1 episode)
#100
Most popular actor on Masters of Sex
216 Wikipedia views yesterday
Helen Wilson
as Dr. Anna Freud (1 episode)
Kirsten Kollender
as Receptionist (1 episode)
Eileen Grubba
as Lucille (1 episode)
Jarard Kings
as Passenger (1 episode)
Alan Ruck
as Psychiatrist (2 episodes)
#24
Most popular actor on Masters of Sex
1,860 Wikipedia views yesterday
John Pollono
as David Haas (1 episode)
#168
Most popular actor on Masters of Sex
19 Wikipedia views yesterday
Brian R. Norris
as Jake Prescott (1 episode)
Shanna Collins
as JoBeth Prescott (1 episode)
#161
Most popular actor on Masters of Sex
26 Wikipedia views yesterday
Micah A. Hauptman
as Kyle (1 episode)
Pepper Binkley
as Adelaide (1 episode)
#189
Most popular actor on Masters of Sex
4 Wikipedia views yesterday
Michael Dunn
as Car Dealer (1 episode)
Mary Catalano
as Myrtle (1 episode)
Alex Chansky
as Thug #1 (1 episode)
Craig Baxley Jr
as Thug #2 (1 episode)
Finn Wittrock
as Dale (4 episodes)
#40
Most popular actor on Masters of Sex
900 Wikipedia views yesterday
Flex Alexander
as Walter (1 episode)
#81
Most popular actor on Masters of Sex
312 Wikipedia views yesterday
Brit Shaw
as Colleen (1 episode)
Gary Kraus
as Dennis (1 episode)
Braden Moran
as Doctor in Lecture (1 episode)
Doug McKeon
as Reverend Peter Mayfair (1 episode)
#31
Most popular actor on Masters of Sex
1,356 Wikipedia views yesterday
Rob Kerkovich
as Jeremy (1 episode)
#116
Most popular actor on Masters of Sex
138 Wikipedia views yesterday
Bennet Guillory
as Eustace (1 episode)
Claire van der Boom
as Shirley (1 episode)
#106
Most popular actor on Masters of Sex
169 Wikipedia views yesterday
For the best insights and data about the TV show Masters of Sex, visit our main Masters of Sex page.