Masters of Sex (TV) Cast
The cast of Masters of Sex. Updated on September 13, 2025.
525 actors
Michael Sheen
as William Masters (46 episodes)

Michael Sheen portrays the character of Dr. William Masters, a renowned fertility expert and a pioneer in the study of human sexuality.

Lizzy Caplan
as Virginia Johnson (46 episodes)

Lizzy Caplan plays the role of Virginia Johnson, Dr. Masters' assistant and eventual research partner. Johnson becomes an influential figure in the field of sexual research.

Caitlin FitzGerald
as Libby Masters (46 episodes)

Caitlin FitzGerald portrays the character of Libby Masters, Dr. Masters' wife. Libby struggles with her own desires and the challenges of their unconventional marriage.

Annaleigh Ashford
as Betty DiMello (37 episodes)

Annaleigh Ashford plays the role of Betty DiMello, a sex worker who becomes an integral part of Dr. Masters and Virginia's research team.

Nicholas D'Agosto
as Dr. Ethan Haas (14 episodes)

Nicholas D'Agosto portrays the character of Dr. Ethan Haas, a young and ambitious doctor who joins Dr. Masters' team and becomes involved in their controversial research.

Teddy Sears
as Dr. Austin Langham (29 episodes)

Teddy Sears plays the role of Dr. Austin Langham, another member of Dr. Masters' team who assists in their groundbreaking research.

Roslyn Ruff
as Josephine May (1 episode)

Roslyn Ruff portrays the character of Josephine May, a patient of Dr. Masters who becomes an active participant in the research studies.

Margo Martindale
as Miss Horchow (1 episode)

Margo Martindale plays the role of Miss Horchow, the head of the university library where Dr. Masters and Virginia conduct much of their research.

Steve Rosen
as Ernie Turk (1 episode)
Johanna Day
as Advisor (1 episode)
Mary Jo McConnell
as Desk Nurse (1 episode)
Jeffrey C. Hawkins
as OR Doctor #1 (1 episode)
Linda Marie Larson
as Lois Tupps (1 episode)
Danae Nason
as Assisting Nurse #1 (1 episode)
Mark Rosing
as Anesthesiologist (1 episode)
Phil McGlaston
as Worker (1 episode)
Duncan Bindbeutel
as Doctor at Party (uncredited) (1 episode)
Roy Pollack
as Upscale Party Goer (uncredited) (1 episode)
Elysia Richards
as Nurse (uncredited) (1 episode)
Tanya Wheelock
as College Student (uncredited) (1 episode)
Matthew Dean Wood
as Party Guest (uncredited) (1 episode)
Elizabeth Dennehy
as (1 episode)
April Parker Jones
as Mrs. Katcher (1 episode)
Ruby Lewis
as Connie (1 episode)
Kristin Slaysman
as Bernadette (1 episode)
Susan-Kate Heaney
as Shirley (1 episode)
Khali Macintyre
as Claire (1 episode)
Debbie Jaffe
as Nurse Grand (1 episode)
Clark Moore
as Officer Burt (1 episode)
Doug Hurley
as John (uncredited) (1 episode)
Mae Whitman
as Patient (1 episode)
Lauren Weedman
as Quadruplets' Mother (1 episode)
Nicholle Tom
as Maureen (2 episodes)
Sara Rae Foster
as Dottie (2 episodes)
Ellen Wroe
as Ginger (2 episodes)
Bobby Campo
as Carl (1 episode)
David Ury
as (1 episode)
Simone Carter
as Arda (1 episode)
Clark Freeman
as Operating Doctor #1 (1 episode)
Natasha Sims
as Operating Nurse (1 episode)
Ori Kalmus
as Reporter (1 episode)
Casey Dolkas
as Photographer (1 episode)
Cleo Fraser
as Vivian Scully (1 episode)
Adam Maurer
as Med Student (uncredited) (1 episode)
Barrett Perlman
as Prostitute (uncredited) (1 episode)
Evie Ryland
as Nursery Visitor (uncredited) (1 episode)
Leah Shaw
as Prostitute (uncredited) (1 episode)
Michael Mantell
as Byron (1 episode)
Martha Hackett
as Shirley (1 episode)
William Nicol
as Assistant Doctor (1 episode)
Emily Bridges
as Velma (1 episode)
Dean Chekvala
as Mr. Zelinsky (1 episode)
Kira Sternbach
as Marjorie (1 episode)
Gabe O'Mara
as Daniel Zelinsky (1 episode)
Monica Hewes
as Sophia Zelinsky (1 episode)
Michael Tower
as Doug (1 episode)
Carolyn Crotty
as Marilyn (1 episode)
Jed Sura
as Assistant Doctor (1 episode)
Tony Robinette
as Nerdy Man (1 episode)
Charlotte Chanler
as Woman (1 episode)
Chris Degner
as Working Class Man (1 episode)
Sarah Allyn Bauer
as Young Woman (1 episode)
Faleena Hopkins
as Young Estabrooks (1 episode)
Christian O'Brien
as Guest (uncredited) (1 episode)
Jorie Stern
as Nurse (uncredited) (4 episodes)
Joseph Lyle Taylor
as Stan (1 episode)
Kyle Jones
as Glenn (1 episode)
Emily Davenport
as Patty (1 episode)
Romina Bovolini
as F-102 (1 episode)
Cheryl Bricker
as Subject 096 (1 episode)
Mike Peebler
as Anesthesiologist (1 episode)
Shaun Rylee
as Scully Family Friend (uncredited) (1 episode)
Barry Bostwick
as Morris (1 episode)
Ann Cusack
as Harriet (1 episode)
Caroline Lagerfelt
as Barb (1 episode)
Leah Costello
as Louise (1 episode)
Rachel Kimsey
as Nessie Lawson (1 episode)
Helen Wilson
as Dr. Anna Freud (1 episode)
Kirsten Kollender
as Receptionist (1 episode)
Eileen Grubba
as Lucille (1 episode)
Jarard Kings
as Passenger (1 episode)
Alan Ruck
as Psychiatrist (2 episodes)
John Pollono
as David Haas (1 episode)
Brian R. Norris
as Jake Prescott (1 episode)
Shanna Collins
as JoBeth Prescott (1 episode)
Micah A. Hauptman
as Kyle (1 episode)
Pepper Binkley
as Adelaide (1 episode)
Michael Dunn
as Car Dealer (1 episode)
Mary Catalano
as Myrtle (1 episode)
Alex Chansky
as Thug #1 (1 episode)
Craig Baxley Jr
as Thug #2 (1 episode)
Finn Wittrock
as Dale (4 episodes)
Flex Alexander
as Walter (1 episode)
Brit Shaw
as Colleen (1 episode)
Gary Kraus
as Dennis (1 episode)
Braden Moran
as Doctor in Lecture (1 episode)
Doug McKeon
as Reverend Peter Mayfair (1 episode)
Rob Kerkovich
as Jeremy (1 episode)
Bennet Guillory
as Eustace (1 episode)
Claire van der Boom
as Shirley (1 episode)
For the best insights and data about the TV show Masters of Sex, visit our main Masters of Sex page.