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Anthony Anderson portrays Andre Johnson, the patriarch of the Johnson family. Andre, also known as Dre, is a successful advertising executive who tries to impart his black cultural identity onto his children while living in a predominantly white neighborhood.

Tracee Ellis Ross plays Rainbow Johnson, Andre's wife and a doctor. Rainbow, often referred to as Bow, is biracial and brings a different perspective to the family dynamic. She is supportive of her husband's desire to maintain their cultural identity while also challenging him to see other perspectives.

Marcus Scribner portrays Junior Johnson, the eldest son of Andre and Rainbow. Junior is portrayed as intelligent but socially awkward, often providing comic relief through his eccentricities. He navigates the complexities of being a young black man in today's society.

Marsai Martin plays Diane Johnson, one of the Johnson twins. Diane is known for her dry and sarcastic sense of humor, often stating uncomfortable truths in a blunt manner. Despite her young age, she is portrayed as extremely smart and wise beyond her years.

Miles Brown portrays Jack Johnson, Diane's twin brother. Jack is the opposite of Diane and is often seen as the more innocent and playful of the two. He brings a light-hearted energy to the show and shares a close bond with his siblings.

Deon Cole plays Charlie Telphy, Dre's co-worker and friend. Charlie is known for his laid-back personality and offbeat sense of humor. He often provides comic relief through his outrageous stories and quirky behavior.

Jenifer Lewis portrays Ruby Johnson, Andre's mother and the grandmother of the Johnson children. Ruby is a spirited woman who often clashes with her daughter-in-law, Bow. Her larger-than-life personality and dramatic antics bring a comedic element to the show.