Malcolm in the Middle (TV) Cast
The cast of Malcolm in the Middle. Updated on September 15, 2025.
1,039 actors
Frankie Muniz
as Malcolm (151 episodes)

Frankie Muniz portrays the titular character, Malcolm, a highly intelligent and academically gifted teenager who struggles to fit in both at school and at home.

Jane Kaczmarek
as Lois (151 episodes)

Jane Kaczmarek portrays Lois, the overbearing yet loving mother of Malcolm and his four siblings. She is known for her strict parenting style and sharp wit.

Bryan Cranston
as Hal (151 episodes)

Bryan Cranston portrays Hal, the quirky and often clueless father of the family. Despite his childlike nature, Hal occasionally surprises everyone with hidden talents.

Justin Berfield
as Reese (151 episodes)

Justin Berfield portrays Reese, the second oldest brother and notorious troublemaker. Reese constantly finds himself in outrageous situations and loves causing mischief.

Erik Per Sullivan
as Dewey (151 episodes)

Erik Per Sullivan portrays Dewey, the youngest brother who possesses an unexpected maturity for his age. Dewey is often involved in his siblings' antics.

Christopher Masterson
as Francis (151 episodes)

Christopher Masterson portrays Francis, the eldest brother and rebel of the family. Francis frequently clashes with his parents and seeks independence away from home.

James Rodriguez
as Jamie (40 episodes)

James Rodriguez portrays Jamie, the youngest member of the family and the new addition in later seasons. Jamie adds a new dynamic to the already chaotic household.

Lukas Rodriguez
as Jamie (40 episodes)

Lukas Rodriguez portrays Jamie, the youngest member of the family and the new addition in later seasons. Jamie adds a new dynamic to the already chaotic household.

Jenna Edwards
as Cheryl (1 episode)
Michael McShane
as Dr. Phelps (1 episode)
Tarah Paige
as Contortionist (1 episode)
Lilyan Chauvin
as Marica (1 episode)
Markus Flanagan
as Frank (1 episode)
Timothy Stack
as Sam (1 episode)
Julia Campbell
as Donna (1 episode)
Travis Van Winkle
as Phillip (1 episode)
Deborah Harmon
as Parent Volunteer (1 episode)
Tim DeKay
as Matt (1 episode)
Christopher Lloyd
as Walter (1 episode)
Jeremy Howard
as Ethan (1 episode)
Hayden Panettiere
as Jessica (4 episodes)
Ana Gabriel
as Woman (1 episode)
Joel McKinnon Miller
as Officer Karl (2 episodes)
Danielle Panabaker
as Kathy McCulskey (1 episode)
Amy Davidson
as Paula (1 episode)
Jerry Trainor
as Guardsman (1 episode)
Octavia Spencer
as Cashier (1 episode)
Susan Yeagley
as Nurse (1 episode)
Stuart Pankin
as Doctor (1 episode)
Jodi Carlisle
as Book Club Lady (1 episode)
Lauren Storm
as Laurie (2 episodes)
Bret Loehr
as Carl (1 episode)
Lindsey Haun
as Kristen (1 episode)
Teresa Ganzel
as Crystal (1 episode)
Kat Graham
as Val (1 episode)
Joan Blair
as Lunch Lady Shirley (1 episode)
Hallie Todd
as Miss Shaw (1 episode)
James Hong
as Mr. Li (1 episode)
Kaitlin Cullum
as Stephanie (1 episode)
Cole Petersen
as Tony (1 episode)
Reggie Jackson
as Reggie Jackson (1 episode)
Regan Burns
as Middle Aged Man (1 episode)
Jorge-Luis Pallo
as Driver (1 episode)
Martin Spanjers
as Richard (1 episode)
Jerry Lambert
as Dave (1 episode)
Rick Scarry
as Preacher (1 episode)
Johnny Lewis
as Martin (1 episode)
Eddie Shin
as Jordan (1 episode)
Bob Cicherillo
as Walt (1 episode)
Art LaFleur
as Fred (1 episode)
Stephen Lee
as Speaker (1 episode)
Matthew McGrory
as Lothar (1 episode)
David Rasche
as Lawyer (1 episode)
Anastasia Baranova
as Sonja (1 episode)
Suzie Pollard
as Hanna (1 episode)
Lamont Thompson
as Cedrick Hampton (1 episode)
Larisa Oleynik
as Abby (1 episode)
Josh Hammond
as Travis (1 episode)
Michael Welch
as Josh (1 episode)
Stuart Fratkin
as Dave (1 episode)
Nolan North
as Leonard Nimoy (voice) (1 episode)
Michaela Watkins
as Receptionist (1 episode)
Zach Mills
as Matt (1 episode)
Jeff Doucette
as Nate (1 episode)
Vanessa Marano
as Gina (1 episode)
Mark Christopher Lawrence
as Sheriff #1 (1 episode)
Florence Stanley
as Mrs. Griffin (1 episode)
Kurt Fuller
as Mr. Young (1 episode)
Sam McMurray
as Off. Stockton (1 episode)
Miriam Flynn
as Cooking Teacher (1 episode)
Alex McKenna
as Beth (1 episode)
Cerina Vincent
as Carly (1 episode)
Ashley Edner
as Kelly (1 episode)
Alexander Gould
as Egg (1 episode)
Peter MacKenzie
as Terry (1 episode)
Dan Butler
as Norm (1 episode)
Jennifer Lyons
as Stripper (1 episode)
Cindy Ambuehl
as Darlene Fisher (1 episode)
Steven Christopher Parker
as Boy (1 episode)
Lisa Foiles
as Mallory (1 episode)
Todd Holland
as Patrick (1 episode)
Blair Wingo
as Amaani (2 episodes)
Harry Groener
as Rudy (1 episode)
Stephen Tobolowsky
as Mr. Fisher (1 episode)
Tania Raymonde
as Cynthia Sanders (5 episodes)
Dylan Cash
as Kid (1 episode)
Shannon Woodward
as Tammy (1 episode)
Logan O'Brien
as Ronnie Demarco (1 episode)
Christopher Michael Moore
as Elroy (2 episodes)
Magic Johnson
as Ringer Hockey Player (2 episodes)
Wayne Wilderson
as Hotel Clerk (1 episode)
Dana Davis
as Chandra (1 episode)
Ryan Malgarini
as Noah (1 episode)
Kyle Searles
as Jason (1 episode)
Todd Stashwick
as Nate (1 episode)
Frederick Koehler
as Mellon (1 episode)
Michael Dempsey
as Teddy (1 episode)
Amy Castle
as Hayley (1 episode)
Andrew James Allen
as Jerome (1 episode)
Aloma Wright
as Nurse (1 episode)
For the best insights and data about the TV show Malcolm in the Middle, visit our main Malcolm in the Middle page.